Buy MDAI (5,6-methylenedioxy-2-aminoindane) Online

$400.00$3,800.00

Buy MDAI (5,6-methylenedioxy-2-aminoindane) Online is an entactogen substance of the aminoindane chemical class that produces entactogenic effects when administered. Buy MDAI Online from Fentanyl World

Clear
SKU: N/A Category:

Description

Buy MDAI (5,6-methylenedioxy-2-aminoindane) Online

Buy MDAI Online

Buy MDAI (5,6-methylenedioxy-2-aminoindane) Online is an entactogen substance of the aminoindane chemical class that produces entactogenic effects when administered. Buy MDAI Online from Fentanyl World

MDAI (5,6-methylenedioxy-2-aminoindane) is a drug developed in the 1990s by a team led by David E. Nichols at Purdue University. It acts as a non-neurotoxic and highly selective serotonin releasing agent (SSRA) in vitro and produces entactogen effects in humans.

The chemical structure of MDAI is indirectly derived from that of the illicit drug MDA, but the alpha-methyl group of the alkyl amino amphetamine side chain has been bound back to the benzene nucleus to form an indane ring system, which changes its pharmacological properties substantially.

MDAI can be produced from 3-(3,4-methylenedioxyphenyl)propionic acid which is converted to the acid chloride and then heated to produce 5,6-Methylenedioxy-1-indanone. Treatment of the indanone with amyl nitrite in methanol with HCl afforded the hydroxyimino ketone. This is reduced to the 2-aminoindan following a modification of Nichols’ earlier method from a paper discussing DOM analogues, using a Pd/C catalyst in glacial acetic acid with catalytic H2SO4.

MDAI has been shown to inhibit the reuptake of serotonin, dopamine, and norepinephrine with IC50 values of 512 nM, 5,920 nM, and 1,426 nM, respectively. This demonstrates that MDAI has selective affinity for the serotonin transporter (SERT). In animals treated with reserpine and MDAI, greater extracellular concentrations of monoamine neural transmitters resulted, most significantly serotonin. This result indicates that MDAI is a potent releaser of serotonin, while effectively inhibiting the reuptake of serotonin. For comparison, MDAI is similar in potency with releasing serotonin to MDA but significantly less potent than MDMA.

The family of drugs typified by MDMA produce their effects through multiple mechanisms of action in the body, and consequently produce three distinct cues which animals can be trained to respond to: a stimulant cue typified by drugs such as methamphetamine, a psychedelic cue typified by drugs such as LSD and DOM, and an “entactogen-like” cue which is produced by drugs such as MDAI and MBDB.

Buy MDAI (5,6-methylenedioxy-2-aminoindane) Online

 

Reviews

There are no reviews yet.

Be the first to review “Buy MDAI (5,6-methylenedioxy-2-aminoindane) Online”

Your email address will not be published. Required fields are marked *

Translate »