how to use fentanyl
  • Before you start the treatment, read the manufacturer’s printed information leaflet from inside the pack. It will give you more information about fentanyl and will provide you with a step-by-step guide on how to use the product you have been supplied with. It will also give you a full list of the side-effects which you may experience from having fentanyl.
  • Take fentanyl exactly as your doctor tells you to. There are several different preparations available, so your doctor or pharmacist will tell you how you should take your doses. When you first start taking fentanyl, your doctor will gradually increase your dose to make sure that you have the dose that eases your pain but minimises any unwanted symptoms. Once you have been told what dose is right for you, keep taking this dose unless you are told otherwise by your doctor.
  • Your dose will be on the label of the pack. Make sure you follow the instructions your doctor has given you carefully. If you are unsure either about your dose or how to use the fentanyl preparation you have been given, ask your pharmacist to explain this to you again.

If you are using fentanyl patches

  • Open the protective pouch carefully and remove the patch. Check that the patch has not been damaged in any way as you have opened the pouch. (Keep the opened pouch to use later to dispose of the patch once it has been used.)
  • Place the patch on a dry, non-hairy, healthy area of skin on your upper arm or upper body. Press it firmly on to your skin for approximately 30 seconds to make sure that it sticks well, especially around the edges. It is important that you avoid touching the sticky side of the patch while you do this. After you’ve applied the patch, wash your hands to make sure you have no fentanyl on your fingers.
  • When you first use a patch, it may take up to 24 hours for the patch to reach its full effect; so, during this time, you may need alternative pain relief. Your doctor will explain this to you.
  • Leave the patch in place for 72 hours (three days), then remove it and apply a new patch to a different area of skin on your upper arm or body. Remember to change the patch at the same time of day every three days.
  • Fold the removed patch in half with the sticky side inwards and put it back into a protective pouch. Dispose of the pouch as you have been directed by your doctor, making sure it is safely out of the reach of any children.
  • Try to make sure that any patch you are wearing does not come into contact with a heat source such as a heating pad, hot water bottle, electric blanket, or a heated water bed. Heated items like these can increase the amount of fentanyl that is released from the patch, which increases the risk of overdose. Having long hot baths, saunas, or sunbathing are also best avoided.
  • Let your doctor know if you develop a high temperature at any time, as this also can increase the amount of fentanyl you absorb from the patch.
  • Each time you collect your prescription, check to make sure you have been given the same brand of fentanyl patches as you have had before. This is because different brands may release different amounts of fentanyl and you should keep to the same brand unless your doctor has advised you otherwise.
  • Signs of having too much fentanyl include shallow or weak breathing, feeling very sleepy or confused, slurred speech and extreme dizziness. If you have any of these effects, remove the patch and contact your doctor straightaway.

If you are using fentanyl lozenges (Actiq®)

  • These lozenges have an applicator attached so that you can move the lozenge around inside your mouth as you suck. Move the applicator around so that the lozenge comes into contact as much as possible with your tongue and the inside of your cheeks. Be careful not to chew or swallow the lozenge. As the lozenge dissolves, fentanyl will be absorbed through the lining of your mouth. If your mouth is dry, it may help to moisten your mouth with a drink of water before you suck the lozenge.
  • Suck one lozenge over a period of about 15 minutes. If your pain has not eased within 15 minutes after having finished this lozenge, suck another lozenge. Do not use more than two lozenges for any episode of pain, or more than four lozenges in any 24-hour period. If your pain is not controlled by this, you must let your doctor know.

If you are using fentanyl sublingual tablets (Abstral®)

  • Place the tablet under your tongue and allow it to dissolve completely. Do not chew, suck or swallow the tablet. You can moisten your mouth with a drink of water before placing the tablet under your tongue, but do not eat or drink anything while the tablet is dissolving.
  • If your pain has not eased within 15-30 minutes, you may use another tablet. Do not use more than two tablets for any episode of pain. If your pain is not controlled by this, you must let your doctor know. If you have another episode of breakthrough pain, it is important that you leave at least two hours after treating the first episode before you treat the further episode. If you are having more than four episodes of breakthrough pain in any 24-hour period, you should let your doctor know about this.

If you are using fentanyl buccal tablets (Effentora®)

  • Place the tablet between your gum and cheek and allow it to dissolve completely. Do not chew, suck or swallow the tablet. You can moisten your mouth with a drink of water before placing the tablet in your mouth, but do not eat or drink anything while the tablet is dissolving. However, if after 30 minutes there are still bits of tablet remaining in your mouth, you can swallow these with a drink of water.
  • If your pain has not eased within 30 minutes, you may use another tablet but use this on the other side of your mouth or, alternatively, place it under your tongue. Do not use more than two tablets for any episode of pain. If your pain is not controlled by this, you must let your doctor know. If you have another episode of breakthrough pain, it is important that you leave at least four hours after treating the first episode before you treat the further episode.

If you are using fentanyl nasal spray (Instanyl® or PecFent®)

  • Use one spray into one of your nostrils. It is best if you sit or stand while you use the spray. Hold the spray upright and bend your head slightly forward. Close one nostril by placing a finger against it and insert the tip of the spray into the other nostril. Press the spray once while you are breathing in through your nose.
  • If your pain has not eased within 10 minutes, use a second spray into the other nostril. Do not use more than two sprays for any episode of pain and do not use the spray again within four hours. If your pain is not controlled by this, you must let your doctor know. Likewise, if you are having more than four episodes of breakthrough pain in any 24-hour period, you should let your doctor know about this too.
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